Cripto antagonism of activin and TGF-b signaling
US7820620B2 · kind B2 · utility
14Cited by
3References
9Claims
0Family size
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Key dates
| Filing date | Sep 14, 2004 |
| Grant date | Oct 26, 2010 |
| Priority date | — |
| Expiry date | Sep 14, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-b complex may enhance antiproliferative effects of activin and TGF-b.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.