Lipid A and other carbohydrate ligand analogs
US7820627B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 9, 2003 |
| Grant date | Oct 26, 2010 |
| Priority date | — |
| Expiry date | Sep 9, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and location of negatively charged groups, and the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents, or lipid A antagonists useful in the treatment of septic shock. In a like manner, a residue of pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest, generating a series of ligand analogs. These are useful, e.g., as haptens, inhibitors of bacterial-host cell adhesion, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.