Urea derivative, process for producing the same, and use

US7820673B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Keiji Kubo · Tsukuba, JP
• Yasuhiro Imaeda · Ann Arbor, US

Key dates

• Filing date: Dec 15, 2004
• Grant date: Oct 26, 2010
• Expiry date: Dec 15, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I):wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is —C(O)—, —S(O)—, or —S(O)2—; W is —N(R2)—, —O—, or a bond (wherein R2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is —C(O)—, —S(O)—, or —S(O)2—; Z is a bond, a chain hydrocarbon group which may be substituted, or —N═; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and[Chemical formula 2], are each independently a single bond or a double bond; provided that R1 may be bonded to R2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.