Gene constructs coding for CD40-binding activating antibodies
US7820807B2 · kind B2 · utility
12Cited by
16References
6Claims
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Key dates
| Filing date | Apr 8, 2009 |
| Grant date | Oct 26, 2010 |
| Priority date | — |
| Expiry date | Apr 8, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.