Patent · US Active

Process for the preparation of chiral 8-(-3-aminopiperidin-1-yl) xanthines

US7820815B2 · kind B2 · utility

69Cited by

73References

13Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Waldemar Pfrengle · Seibersbach, DE
Thorsten Pachur · Biberach an der Riß, DE
Thomas Nicola · Ingelheim am Rhein, DE
Adil Duran · Biberach an der Riß, DE

Key dates

Filing date	Nov 4, 2005
Grant date	Oct 26, 2010
Priority date	—
Expiry date	Jun 28, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/07
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines. The process involves reacting a compound of the formula (III) with 3-(phthalimido)piperidine or an enantiomer thereofwhere X is a leaving group selected from halogens and sulphonic ester acid residues, and R1 to R3 are as defined herein, to obtain a compound of the formula (II)and deprotecting the obtained compound of the formula (II) to obtain the product xanthines.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.