Substituted nucleic acid mimics
US7825215B1 · kind B1 · utility
4Cited by
4References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 8, 1996 |
| Grant date | Nov 2, 2010 |
| Priority date | — |
| Expiry date | Mar 8, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for the nucleic acid mimic determination of nucleic acids. The compositions and methods may be used in the diagnosis and treatment of diseases amenable through modulation of nucleic acids which encode proteins that are implicated in disease states. In accordance with preferred embodiments, mimics are comprised of non-naturally occurring backbones to which are appended modified heterocyclic bases. Such bases preferably have sterically bulky substituents 1, 2, or 3 atoms removed from the sites of attachment to the backbone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.