Substituted enaminones, their derivatives and uses thereof

US7825278B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Derk Hogenkamp · Carlsbad, US
• Timothy B. C. Johnstone · Brooks Road, US
• Kelvin W. Gee · Irvine, US

Key dates

• Filing date: May 5, 2005
• Grant date: Nov 2, 2010
• Expiry date: Apr 14, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of γ-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.