Method of treating an IL-1 related cancer

US7829094B2 · kind B2 · utility

Assignee

• XOMA TECHNOLOGY LTD. · US

Inventors

• Linda Masat · Walnut Creek, US
• Mary Haak-Frendscho · Madison, US
• Arnold Horwitz · San Leandro, US
• Gang Chen · Sammamish, US
• Marina Roell · Concord, US

Key dates

• Filing date: May 11, 2009
• Grant date: Nov 9, 2010
• Expiry date: May 11, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.