Method of forming iron oxide core metal shell nanoparticles
US7829140B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 29, 2006 |
| Grant date | Nov 9, 2010 |
| Priority date | — |
| Expiry date | Jun 21, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC01P2006/42
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of forming mono-disperse iron-oxide core metal shell nanoparticles is disclosed. Particle size of the oxide core seeds is controlled and capped seeds are formed. The capping layer is desorbed by a thermally activated process and metal such as gold is chemically deposited on the core seeds in situ. This process can be repeated to produce multi-metal or different metal shells. A second capping layer is applied on the core/shell composite nanoparticles. In another step, the particles are sized by centrifuging to obtain a tightly controlled and narrow particle size distribution. The water-dispersibility of the particles is achieved by a thiol exchange reaction on the gold shell of the core/shell nanoparticles or by deposition of gold on ferritin-derived iron oxide cores in aqueous solution. Mono and multilayer thin films are assembled on different substrates using the core/shell particles and linking molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.