Patent · US Active

Drug testing with bio-artificial organ slices including for example those derived from liver

US7829325B2 · kind B2 · utility

0Cited by
8References
11Claims
0Family size

Assignee

Inventor

Key dates

Filing dateAug 24, 2005
Grant dateNov 9, 2010
Priority date—
Expiry dateMar 6, 2027

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N33/5082
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A drug testing system using any number of bio-artificial organs, for example liver-slices based in a culture apparatus. The apparatus has a chamber with plasma and gas valves, animal organ slices being positioned securely in the chamber so as to maximize the surface area of organ slices exposed to the culture medium. Plasma is supplied to the chamber so that it rises to contact the organ slices, and is alternately removed from contacting the organ slices. Gas is supplied to the top of the chamber. The system also includes a reservoir for containing media entering and exiting the chamber. Methods are provided for assessing the toxicity of a drug or drug candidate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.