Modulation of hedgehog-mediated signaling pathway
US7829333B2 · kind B2 · utility
0Cited by
5References
20Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | May 22, 2006 |
| Grant date | Nov 9, 2010 |
| Priority date | — |
| Expiry date | Jun 26, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.