Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-fungal agents
US7829503B2 · kind B2 · utility
0Cited by
20References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 26, 2004 |
| Grant date | Nov 9, 2010 |
| Priority date | — |
| Expiry date | Sep 10, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6897
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for screening and identifying compounds that modulate the activity of a fungal tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit or reduce the activity of a fungal tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for preventing, treating, managing and/or ameliorating a fungal infection or fungal infestation or one or more symptoms thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.