Drug targeting
US7829555B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 13, 1998 |
| Grant date | Nov 9, 2010 |
| Priority date | — |
| Expiry date | Feb 13, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/559
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier. Also provided by the invention are novel bioreductive conjugates comprising a non-cytotoxic bioreductive moiety with linked-thereto at least one therapeutic agent. The compounds of the invention are particularly suitable for the treatment of rheumatoid arthritis and other arthritic conditions, diabetes, atherosclerosis, stroke, sepsis, Alzheimer's disease and other neurological disorders, cancer, kidney disease, digestive diseases, liver disease, chronic periodontitis or ischemia following tissue transplantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.