Sirtuin modulating compounds

US7829556B2 · kind B2 · utility

Assignee

• Sirtris Pharmaceuticals, Inc. · US

Inventors

• Jean E. Bemis · Arlington, US
• Jeremy S. Disch · Natick, US
• Michael R. Jirousek · Cambridge, US
• Walter Joseph Lunsmann · Harvard, US
• Pui Yee Ng · Waltham, US
• Chi B. Vu · Cambridge, US

Key dates

• Filing date: Jun 20, 2008
• Grant date: Nov 9, 2010
• Expiry date: Jun 20, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.