Indole derivatives as serotonin reuptake inhibitors

US7829565B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Timo Heinrich · Groß-Umstadt, DE
• Henning Bottcher · Darmstadt, DE
• Kai Schiemann · Darmstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Christoph van Amsterdam · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Joachim Leibrock · Gauting, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE

Key dates

• Filing date: May 24, 2004
• Grant date: Nov 9, 2010
• Expiry date: Jan 28, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I), the use thereof for the preparation of a medicament for the treatment of diseases associated with the serotonin receptor and/or serotonin reuptake, in particular for the preparation of a medicament as anxiolytic, antidepressant, neuroleptic and/or antihypertonic and/or for positively influencing obsessive-compulsive disorder (OCD), sleeping disorders, tardive dyskinesia, learning disorders, age-dependent memory disorders, eating disorders, such as bulimia, and/or sexual dysfunctions. The compounds bind to the 5-HT1A receptor.