Polycationically charged polymer and the use of the same as a carrier for nucleic acid

US7829657B2 · kind B2 · utility

Assignee

• THE UNIVERSITY OF TOKYO · JP

Inventors

• Kazunori Kataoka · Bunkyo, JP
• Keiji Itaka · Tokyo, JP
• Nobuhiro Nishiyama · Tokyo, JP
• Shigeto Fukushima · Narashino, JP
• Woo-Dong Jang · Tokyo, JP
• Kanjiro Miyata · Tokyo, JP
• Masataka Nakanishi · Kariya, JP
• Shunsaku ASANO · Tokyo, JP
• Naoki Kanayama · Wako, JP

Key dates

• Filing date: Feb 8, 2006
• Grant date: Nov 9, 2010
• Expiry date: Dec 11, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/88
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to the main chain either directly or via a linker. The disclosed composition has low toxicity, and has a high efficiency in introducing nucleic acid into cells.