Patent · US Active

Immunogenic lipopeptides comprising T-helper and cytotoxic T lymphocyte (CTL) epitopes

US7833532B2 · kind B2 · utility

4Cited by

3References

32Claims

0Family size

Assignee

The Council of the Queensland Institute of Medical Research · AU

Inventors

David Charles Jackson · Elmore, AU
Weiguang Zeng · Sydney, AU

Key dates

Filing date	Aug 12, 2003
Grant date	Nov 16, 2010
Priority date	—
Expiry date	Sep 8, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2770/24234
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and CTL epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular CTL epitopes. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.