Bioactive agent release coating and controlled humidity method

US7833548B2 · kind B2 · utility

Assignee

• Surmodics, Inc. · US

Inventors

• Ralph A. Chappa · Prior Lake, US
• Robert W. Hergenrother · Eden Prairie, US
• Aron B. Anderson · Minnetonka, US
• Linh V. Tran · Brooklyn Park, US
• Laurie R. Lawin · New Brighton, US
• Ronald F. Ofstead · Windom, US

Key dates

• Filing date: Aug 19, 2005
• Grant date: Nov 16, 2010
• Expiry date: May 13, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/606
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).