Methods to evaluate cytochrome P450 2C19 isoenzyme activity using a breath test
US7833744B2 · kind B2 · utility
1Cited by
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22Claims
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Key dates
| Filing date | Aug 31, 2007 |
| Grant date | Nov 16, 2010 |
| Priority date | — |
| Expiry date | Dec 5, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/204998
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates, generally to a method of determining and assessing cytochrome P450 2C19-related (CYP2Cl9) metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by the subject upon intravenous or oral administration of a 13C-labeled CYP2C19 substrate compound. The present invention is useful as a non-invasive, in vivo assay for evaluating CYP2C19 enzyme activity in a subject using the metabolite 13CO2 in expired breath, to phenotype individual subjects and to determine the selection, optimal dosage and timing of drug administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.