Indoline compound and process for producing the same
US7834193B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 16, 2007 |
| Grant date | Nov 16, 2010 |
| Priority date | — |
| Expiry date | Dec 15, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P13/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an industrial method production of silodosin, which is useful for a therapeutic agent for dysuria associated with benign prostatic hyperplasia. The production of silodosine is characterized by mixing 3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indol-1-yl}-propyl benzoate and oxalic acid to yield the oxalate, subsequently hydrolyzing the oxalate salt to yield 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indole-7-carbonitrile and hydrolyzing the same, and manufacturing intermediates used therefore.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.