Partially loaded antibodies and methods of their conjugation
US7837980B2 · kind B2 · utility
76Cited by
1References
26Claims
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Key dates
| Filing date | Mar 2, 2005 |
| Grant date | Nov 23, 2010 |
| Priority date | — |
| Expiry date | Apr 19, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.