Acetylcholinesterase (ACHE)-derived peptide as an inducer of granulocytopoiesis, uses and methods thereof

US7838493B2 · kind B2 · utility

Assignees

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL
• The Medical Research Fund at the Tel-Aviv Sourasky Medical Center · IL

Inventors

• Hermona Soreq · Nesher, IL
• Dan Grisaru · Herzliya, IL
• Varda Deutsch · Jerusalem, IL
• Chava Perry · Ramat Gan, IL
• Marjorie Pick · Jerusalem, IL

Key dates

• Filing date: Feb 10, 2005
• Grant date: Nov 23, 2010
• Expiry date: Dec 17, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/01007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.