Methods of treating cancer and related methods

US7838527B2 · kind B2 · utility

Assignee

• Novartis Vaccines and Diagnostics, Inc. · US

Inventors

• Alison Hannah · Sebastopol, US
• Eric Harwood · Seattle, US
• Peter E. Haroldsen · Pacifica, US
• Carla Heise · Benicia, US
• Timothy Machajewski · Martinez, US
• Emil Samara · Danville, US
• Xiao Shang · Bellevue, US
• Jayesh Vora · Martinez, US
• Shuguang Zhu · Seattle, US

Key dates

• Filing date: Nov 12, 2003
• Grant date: Nov 23, 2010
• Expiry date: Feb 13, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of treating cancer using 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one are provided. In particular, the methods are effective for the treatment of solid tumors or leukemias, including prostate, colorectal, breast, multiple myeloma, pancreatic, small cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, or myelo-proliferative disease. Further provided are methods of measuring the amount of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one and determining a metabolic profile therefore.