Patent · US Active

Substituted bicyclic 8-pyrrolidinoxanthines, methods for their production, pharmaceutical formulations and their use

US7838528B2 · kind B2 · utility

0Cited by

4References

7Claims

0Family size

Assignee

Sanofi-Aventis Deutschland GMBH · DE

Inventors

Karl Schoenafinger · Alzenau, DE
Gerhard Jaehne · Frankfurt, DE
Elisabeth Defossa · Idstein, DE
Lothar Schwink · Stadtallendorf, DE
Holger Wagner · Mettenberg, DE
Christian Buning · Frankfurt am Main, DE
Georg Tschank · Frankfurt am Main, DE
Ulrich Werner · Frankfurt am Main, DE

Key dates

Filing date	Jan 17, 2007
Grant date	Nov 23, 2010
Priority date	—
Expiry date	Jan 9, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I:wherein the various R groups are hereinafter defined. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds. Particular blood glucose disorders treatable thereby include type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerotic diseases and the like.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.