Single-chain multiple antigen-binding molecule, its preparation and use

US7838637B2 · kind B2 · utility

Assignee

• Affitech Research AS · NO

Inventors

• Roland Kontermann · Jeffery Road, DE
• Hans-Harald Sedlacek · Marburg, DE
• Rolf Mueller · Ingolstadt, DE

Key dates

• Filing date: Jun 30, 2004
• Grant date: Nov 23, 2010
• Expiry date: Jul 19, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the form of a VH-VL construct, which are in turn connected together via a peptide, and to the preparation and use thereof as pharmaceutical or diagnostic aid.