Function of autophagy genes in cell death
US7838645B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | May 2, 2005 |
| Grant date | Nov 23, 2010 |
| Priority date | — |
| Expiry date | May 2, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.