Patent · US Active

Methods for producing gamma-carboxylated proteins

US7842477B2 · kind B2 · utility

4Cited by

16References

67Claims

0Family size

Assignee

ASTRAZENECA AB · SE

Inventors

Christel Fenge · Malung, SE
Ann Lövgren · Timrå, SE
Anders Thelin · Sundbyberg, SE

Key dates

Filing date	Oct 14, 2004
Grant date	Nov 30, 2010
Priority date	—
Expiry date	Jul 2, 2026

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and γ-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.