Patent · US Active

Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof

US7842489B2 · kind B2 · utility

44Cited by

23References

7Claims

0Family size

Assignee

CELLECTIS · FR

Inventors

Sylvain Arnould · Paris, FR
Sylvia Bruneau · Paris, FR
Jean-Pierre Cabaniols · Fontenille, FR
Patrick Chames · Marseilles, FR
Andre Choulika · Paris, FR
Philippe Duchateau · Étampes, FR
Jean-Charles Epinat · Paris, FR
Agnes Gouble · Paris, FR
Emmanuel Lacroix · Paris, FR
Frederic Paques · Bourg-la-Reine, FR
Christophe Perez-Michaut · Paris, FR
Julianne Smith · New York, US
David Sourdive · Levallois-Perret, FR

Key dates

Filing date	Feb 23, 2010
Grant date	Nov 30, 2010
Priority date	—
Expiry date	Feb 23, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y301/21004
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y (SEQ ID NO: 23 is residues 1-153 of pdb Ig9y) and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y (SEQ ID NO: 23 is residues 1-153 of pdb Ig9y) in a single polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.