Substituted pyrazole compounds

US7842695B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Oliver Schadt · Rodenbach, DE
• Michael Arlt · Seeheim-Jugenheim, DE
• Dirk Finsinger · Darmstadt, DE
• Kai Schiemann · Darmstadt, DE
• Christoph van Amsterdam · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE

Key dates

• Filing date: Mar 10, 2004
• Grant date: Nov 30, 2010
• Expiry date: Apr 29, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) and salts thereof, in which the following definitions apply: X is N or CH; R1 is H, A, Hal, (CH2)nHet, (CH2)nAr, C3-7-cycloalkyl, CF3, NO2, CN, C(NH)(OH), or OCF3; R2 is (CH2)nHet, (CH2)nAr, or C3-7-cycloalkyl, or CF3; R3 and R4 denote H or an organic radical. Compounds of formula (I) are useful as ligands of 5-HT receptors and useful in the treatment of disorders such as anxiety, depression, obsessive-compulsive disorder and pain.