Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof

US7842805B2 · kind B2 · utility

Assignees

• Myrexis, Inc. · US
• EpiCept Corporation · US

Inventors

• Sui Xiong Cai · San Diego, US
• Mark B. Anderson · Salt Lake City, US
• Adam Willardsen · Sandy, US
• Songchun Jiang · San Diego, US
• Robert J. Halter · Salt Lake City, US
• Rachel Slade · Salt Lake City, US
• Yevgeniya Klimova · Sandy, US

Key dates

• Filing date: Jul 3, 2007
• Grant date: Nov 30, 2010
• Expiry date: Jul 3, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D253/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.