Anti-migraine spirocycles

US7842808B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Prasad V. Chaturvedula · Exton, US
• Ling Chen · Shanghai, CN
• Rita Civiello · Killingworth, US
• Andrew P. Degnan · New Haven, US
• Gene M. Dubowchik · Middlefield, US
• Xiaojun Han · Cheshire, US
• Xiang Jun J. Jiang · North Haven, US
• Guanglin Luo · Newtown, US
• John E. Macor · Guilford, US
• Graham S. Poindexter · Old Saybrook, US
• George O. Tora · Langhorne, US

Key dates

• Filing date: Jan 5, 2007
• Grant date: Nov 30, 2010
• Expiry date: Sep 29, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2807
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of Formula (I)as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.