Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex
US7846201B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 14, 2005 |
| Grant date | Dec 7, 2010 |
| Priority date | — |
| Expiry date | Oct 7, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5094
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.