Method for producing solid galenic formulations using a crosslinked non-thermoplastic carrier

US7846477B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Jörg Rosenberg · Ellerstadt, DE
• Gunther Berndl · Herxheim, DE
• Markus Mägerlein · Mannheim, DE

Key dates

• Filing date: Oct 9, 2003
• Grant date: Dec 7, 2010
• Expiry date: Feb 8, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2027
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns a method for producing solid galenic formulations which consists in: forming a processable paste comprising a) 50 to 99.4 wt. % of at least one non-thermoplastic carrier, b) 0.5 to 30 wt. % of at least an adjuvant selected among thermoplastic polymers, lipids, sugar alcohols and solubilizing agents, c) 0.1 to 49.5 wt. % of at least one active principle, at a temperature not less than the softening temperature of the adjuvant but rising to at least 70° C.; then in cooling the resulting paste. Said solid galenic formulations quickly disintegrate in an aqueous medium.