Multimeric oleamide derivative having connexin-26 inhibiting potency and use thereof in cancer therapy, etc
US7846972B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 1, 2005 |
| Grant date | Dec 7, 2010 |
| Priority date | — |
| Expiry date | Sep 18, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA23V2002/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to multimeric oleamide derivatives having connexin 26 inhibitory activities and embraces the dimer oleamide derivatives represented by the following formula (1) or a pharmacologically acceptable salt thereof:where n denotes an integer of 3, 5, or 8. The novel oleamide derivatives of the present invention can be used not only as research reagents, but also in a wide industrial field because they exhibit useful bioactivities such as cancer metastasis/growth inhibition. Thus they have various applications, such as in medicines, supplements, and functional foods, in addition to cancer-preventive and cancer-therapeutic drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.