Method for preparation of F-18 containing organofluoro compounds in alcohol solvents
US7847092B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 9, 2005 |
| Grant date | Dec 7, 2010 |
| Priority date | — |
| Expiry date | May 13, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/05
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.