Patent · US Active

Industrial preparation of 11-[4-{2-(2-hydroxyethoxy) ethyl}-1-piperazinyl] dibenzo [b,f]-[1,4]thiazepine

US7847094B2 · kind B2 · utility

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1References

16Claims

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Assignee

IPCA LABORATORIES LIMITED · IN

Inventors

Ashok Kumar · Jamkhed, IN
Dharmendra Singh · Mumbai, IN
Swapnali Hemant Patil · Jamkhed, IN
Ganesh Devidas Mahale · Jamkhed, IN
Uttamrao Sawant · Jamkhed, IN
Balasaheb Ganpat Jadhav · Jamkhed, IN
Ragneshkumar Rana · Jamkhed, IN

Key dates

Filing date	Jun 8, 2007
Grant date	Dec 7, 2010
Priority date	—
Expiry date	May 21, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D281/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed herein is an industrial preparation of Quetiapine by the reaction of 11-piperazinyldibenzo[b,f][1,4]-thiazepine or its salt with 2-(2-chloroethoxy)ethanol in presence of an organic or inorganic base under neat or aqueous condition to form 11-[4-{2-(2-hydroxyethoxy)ethyl}-1-piperazinyl]dibenzo[b,f]-[1,4]thiazepine. The quetiapine free base obtained is further converted to its hemi-fumarate salt.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.