Patent · US Active

Process for preparation of atovaquone and novel intermediates thereof

US7847127B2 · kind B2 · utility

1Cited by

4References

21Claims

0Family size

Assignee

IPCA LABORATORIES LIMITED · IN

Inventors

Ashok Kumar · Jamkhed, IN
Suneel Yeshwant Dike · Jamkhed, IN
Pramil Mathur · Mumbai, IN
Nellithanath Thankachen Byju · Mumbai, IN
Brajesh Sharma · Mumbai, IN
Swapnil Shreekant Kore · Mumbai, IN
Vitthal Suryabhan Buchude · Mumbai, IN
Dharmendra Singh · Mumbai, IN

Key dates

Filing date	Oct 21, 2009
Grant date	Dec 7, 2010
Priority date	—
Expiry date	Oct 21, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C50/24
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as “Form IPCA-ATO,” and the preparation thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.