Soluble GP130 molecule variants useful as a medicament

US7851182B2 · kind B2 · utility

Assignee

• CONARIS Research Institute AG · DE

Inventors

• Dirk Seegert · Dänischenhagen, DE
• Georg Waetzig · Kiel, DE

Key dates

• Filing date: Dec 22, 2006
• Grant date: Dec 14, 2010
• Expiry date: Feb 2, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polypeptide-dimer built of two identical monomeric fragments comprising the domains 1 to 3 of the extracellular (soluble) part of glycoprotein (gp)130 and a certain polypeptide spacer are described, which are covalently linked with each other and which bear significant advantages concerning their production rate in host cells, their improved purification and their potential to bind to IL-6/soluble IL-6 receptor complexes. Furthermore, a pharmaceutical composition containing said dimeric molecule and various medical uses are described.