Immunogenic polypeptides encoded by MAGE minigenes and uses thereof

US7851212B2 · kind B2 · utility

Assignees

• Sanofi Pasteur, Inc. · US
• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Neil Berinstein · Toronto, CA
• James Tartaglia · Schenectady, US
• John A. Tine · Scotia, US
• Philippe Moingeon · Verrières-le-Buisson, FR
• Thierry Boon-Falleur · Brussels, BE
• Pierre Vander Bruggen · Brussels, BE

Key dates

• Filing date: May 7, 2001
• Grant date: Dec 14, 2010
• Expiry date: Aug 3, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/023
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention discloses immunogenic polypeptides comprising several MAGE-specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.