Gangliosides with a modified acyl function

US7851450B2 · kind B2 · utility

Assignee

• N.V. Nutricia · NL

Inventors

• Christopher Beerman · Neu-Anspach, DE
• Lars Bode · San Diego, US
• Günther Boehm · Echzell, DE

Key dates

• Filing date: May 27, 2003
• Grant date: Dec 14, 2010
• Expiry date: Jul 20, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a ganglioside mixture, consisting of gangliosides, of the following general formula: (sugar)-OCH2—CH(—NH—CO—R1)—CH(OH)—CH═CH—R2, wherein (sugar) represents a sugar radical, the group —CO—R1 represents an acyl-fatty acid which is bonded to the radical of the molecule in the form of an amide, R1 represents a straight saturated alkyl radical having at least 10 C-atoms and R2 represents a straight, saturated alkyl radical having at least 10 C-atoms or a straight alkenyl radical having at least 10 C-atoms and one, two or three double bond(s). Said mixture is characterised in that at least 10 wt. % of the gangliosides of the general formula I are of the group —CO—R1 and the acyl-fatty acids are a C20:0 fatty acid. Said mixtures exhibit an improved biological activity.