Dipiperazinyl ketones and related analogues

US7851474B2 · kind B2 · utility

Assignee

• Neurogen Corporation · US

Inventors

• Linghong Xie · Guilford, US
• Joseph W. Ochterski · Middlefield, US
• Yang Gao · Hangzhou City, CN
• Bingsong Han · Westwood, US
• Timothy Caldwell · Fishers, US
• Yuelian Xu · Zhejiang, CN
• John M. Peterson · Madison, US
• Ping Ge · Durham, US
• Robert Ohliger · Deep River, US

Key dates

• Filing date: Jul 28, 2006
• Grant date: Dec 14, 2010
• Expiry date: Jul 28, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/107
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).