Certain chemical entities, compositions, and methods

US7851484B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Bradley P. Morgan · Moraga, US
• David J. Morgans, Jr. · Los Altos, US
• Gustave Bergnes · Pacifica, US
• Alex Muci · South San Francisco, US
• Scott Collibee · South San Francisco, US
• Pu-Ping Lu · Foster City, US
• Luke W. Ashcraft · San Francisco, US
• William F. Browne, IV · Tannersville, US
• Marc Garard · San Leandro, US

Key dates

• Filing date: Mar 28, 2008
• Grant date: Dec 14, 2010
• Expiry date: Sep 23, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P21/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.