Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals

US7851493B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Patrick Bernardelli · Fontenay-aux-Roses, FR
• Stefanie Keil · Frankfurt am Main, DE
• Matthias Urmann · Eschborn, DE
• Hans Matter · Langenselbold, DE
• Wolfgang Wendler · Bad Camberg, DE
• Maike Glien · Frankfurt am Main, DE
• Karen Chandross · Somerville, US
• Lan-Ying Lee · Somerville, US
• Corinne Terrier · Livry-Gargan, FR
• Herve Minoux · Thiais, FR

Key dates

• Filing date: May 29, 2009
• Grant date: Dec 14, 2010
• Expiry date: May 29, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity.What are described are compounds of the formula I,in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.