Patent · US Active

Synthetic process for anticancer drug fluorapacin and trisulfide derivatives

US7851657B2 · kind B2 · utility

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26Claims

0Family size

Assignee

ACEA Biosciences, Inc. · US

Inventors

Haoyun An · Beijing, CN
Xiaopeng Mo · Zhejiang, CN

Key dates

Filing date	Mar 27, 2009
Grant date	Dec 14, 2010
Priority date	—
Expiry date	Mar 27, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C323/07
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention provides a synthetic and manufacturing process for the preparation of the anticancer drug, fluorapacin, bis(4-fluorobenzyl)trisulfide, and related trisulfide derivatives on large scale. Also provided are processes for the purification and isolation of fluorapacin having high purity and improved stability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.