Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof

US7854934B2 · kind B2 · utility

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• Samuel J. Danishefsky · New Haven, US
• Don M. Coltart · New York, US
• Stacy Jo Keding · New York, US
• Kaustav Biswas · Thousand Oaks, US
• Philip O. Livingston · New York, US
• Govindaswami Ragupathi · New York, US
• Jennifer R. Allen · Newbury Park, US
• Lawrence Williams · New York, US

Key dates

• Filing date: Jul 31, 2002
• Grant date: Dec 21, 2010
• Expiry date: May 28, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/11
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel glycosides and glycoconjugates, glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, preferably for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need, an effective amount of any of the inventive glycopeptides as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier.