Controlled surface chemical gradients
US7854959B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 31, 2004 |
| Grant date | Dec 21, 2010 |
| Priority date | — |
| Expiry date | Oct 20, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2610/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A simple and reproducible preparative method for the fabrication of surface-chemical gradients is described herein. Surface-chemical gradient films are prepared by using a liquid front in relative motion to the substrate (e.g. immersion by a linear-motion drive or the use of a spreading droplet) to gradually expose substrate samples to very dilute solutions of adsorbates. As demonstrated by XPS, the self-assembled monolayer gradients produced in this way display a high packing density. This method can be used in the preparation of other gradients of various chemical or biochemical functionalities in one or two dimensions. Such gradients can be used in a wide variety of applications in such diverse areas as cell motility studies, nanotribology research, and high-throughput screening.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.