Macrolactams by engineered biosynthesis
US7855192B2 · kind B2 · utility
2Cited by
9References
8Claims
0Family size
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Key dates
| Filing date | Jan 23, 2008 |
| Grant date | Dec 21, 2010 |
| Priority date | — |
| Expiry date | Oct 18, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D225/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.