IL-15 mutants having agonists/antagonists activity
US7858081B2 · kind B2 · utility
36Cited by
3References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 10, 2005 |
| Grant date | Dec 28, 2010 |
| Priority date | — |
| Expiry date | Jan 22, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLIL68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.