4-substituted tetracyclines and methods of use thereof

US7858601B2 · kind B2 · utility

Assignee

• Paratek Pharmaceuticals, Inc. · US

Inventors

• Joel Berniac · Stoneham, US
• Beena Bhatia · Mansfield, US
• Mark Grier · San Diego, US
• Mark L. Nelson · Norfolk, US
• Jingwen Pan · North Grafton, US

Key dates

• Filing date: Oct 25, 2005
• Grant date: Dec 28, 2010
• Expiry date: Dec 1, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.