Therapeutic pyrazolonaphthyridine derivatives
US7858614B2 · kind B2 · utility
1Cited by
5References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 6, 2008 |
| Grant date | Dec 28, 2010 |
| Priority date | — |
| Expiry date | Jul 3, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the α5 subtype of GABAA, and use of the compound of formula I for the treatment of GABAA receptor associated disorders. The general structure of formula I is shown below:The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.